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XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole

机译：XRCC1缺乏症使人肺上皮细胞对遗传毒性的鳄鱼皮石棉和利比角闪石

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Background: Asbestos induces DNA and chromosomal damage, but the DNA repair pathways protecting human cells against its genotoxicity are largely unknown. Polymorphisms in XRCC1 have been associated with altered susceptibility to asbestos-related diseases. However, it is unclear whether oxidative DNA damage repaired by XRCC1 contributes to asbestos-induced chromosomal damage.

机译：背景：石棉会诱导DNA和染色体损伤，但是保护人类细胞免受其遗传毒性影响的DNA修复途径尚不清楚。 XRCC1中的多态性与对石棉相关疾病的易感性变化有关。但是，尚不清楚XRCC1修复的氧化DNA损伤是否导致石棉诱导的染色体损伤。

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Pietruska, Jodie R.; Johnston, Tatiana; Zhitkovich, Anatoly; Kane, Agnes B.;
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年度 2010
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正文语种 {"code":"en","name":"English","id":9}
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1. XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole. [J] . Pietruska JR, Johnston T, Zhitkovich A, Environmental health perspectives. . 2010 ,第12期

机译：XRCC1缺乏症会使人肺上皮细胞对青石棉石棉和利比角闪石的遗传毒性敏感。
2. XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole [J] . Jodie R. Pietruska, Tatiana Johnston, Anatoly Zhitkovich, Environmental health perspectives. . 2010 ,第12期

机译：XRCC1缺乏症使人肺上皮细胞对遗传毒性的鳄鱼皮石棉和利比角闪石
3. Cyto-genotoxicity of amphibole asbestos fibers in cultured human lung epithelial cell line: role of surface iron. [J] . Srivastava RK, Lohani M, Pant AB, Toxicology and Industrial Health . 2010 ,第9期

机译：闪石棉石棉纤维在培养的人肺上皮细胞系中的细胞遗传毒性：表面铁的作用。
4. Aspects of exposure measurement error in epidemiologic cohort analyses using the Libby amphibole asbestos worker cohort, Influence of changes in exposure assess [C] . Thomas Bateson, Leonid Kopylev Annual conference of the International Society of Exposure Science . 2014

机译：使用Libby角闪石棉石棉工人队列的流行病学队列分析中暴露测量误差的方面，暴露变化的影响评估
5. Gene expression analysis of human non -small cell lung cancer subtypes, adenocarcinoma and squamous cell carcinoma, and mouse lung epithelial cell lines: Implications in lung tumorigenesis [D] . Silvers, Amy Lynn. 2002

机译：人类非小细胞肺癌亚型，腺癌和鳞状细胞癌以及小鼠肺上皮细胞系的基因表达分析：在肺肿瘤发生中的意义
6. XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole [O] . Jodie R. Pietruska, Tatiana Johnston, Anatoly Zhitkovich, 2018

机译：XRCC1缺乏症使人肺上皮细胞对遗传毒性的鳄鱼皮石棉和利比角闪石
7. In vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells [O] . Kelly E Duncan, Philip M Cook, Stephen H Gavett, 2014

机译：石棉纤维毒性的体外决定因素：对原代人气道上皮细胞中Libby闪石的相对毒性的影响
8. Health Hazard Evaluation Report: HETA-2012-0077-3223, October 2014. Evaluation of Employee Exposures to Libby Amphibole Asbestos During Forest Management Activities in the Kootenai National Forest. [R] . Butler, C., McCleery, R. E., Kiefer, M., 2014

机译：健康危害评估报告：HETa-2012-0077-3223，2014年10月。在Kootenai国家森林的森林管理活动期间对Libby闪石石棉员工暴露的评估。

XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole

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